Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Chen, Shuying; Xing, Haiyan; Li, Shouyun; Yu, Jing; Li, Huan; Liu, Shuang; Tian, Zheng; Tang, Kejing; Rao, Qing; Wang, Min; Wang, Jianxiang
• Is Part Of: Leukemia research. Volume 39:Issue 9(2015:Sep.)
• Page Start: 976
• Page End: 983
• Publication Date: 2015-09
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.004
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The protein expression of A20 is upregulated in ALL patients and cell lines.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">A20 depletion decreases proliferation of ALL cells both in vivo and in vitro.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">A20 depletion induces cell cycle arrest at G0/G1 stage of ALL cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">A20 depletion increases the sensitivity of ALL cells to chemotherapy.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">The regulation mechanism of A20 was associated with p-ERK and p53 signal pathways.</p> </list-item> </list> </p> </sec> </abstract>