Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Chen, Cai; Bartenhagen, Christoph; Gombert, Michael; Okpanyi, Vera; Binder, Vera; Röttgers, Silja; Bradtke, Jutta; Teigler-Schlegel, Andrea; Harbott, Jochen; Ginzel, Sebastian; Thiele, Ralf; Husemann, Peter; Krell, Pina F.I.; Borkhardt, Arndt; Dugas, Martin; Hu, Jianda; Fischer, Ute
• Is Part Of: Leukemia research. Volume 39:Issue 9(2015:Sep.)
• Page Start: 990
• Page End: 1001
• Publication Date: 2015-09
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.005
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Recurrent hyperdiploid ALL genomics analyzed by next generation sequencing.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Frequent disturbance of the RAS pathway and epigenetic regulation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Structural variations affected B cell developmental genes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Chromothripsis indicated a case of germline TP53 mutated Li Fraumeni-like syndrome.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">In children somatic and predisposing germline variations may contribute to relapse.</p> </list-item> </list> </p> </sec> </abstract>