Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)1. Issue 46 (11th June 2015)

• Record Type: Journal Article
• Authors: Chiou, Jiachi; Wan, Shengbiao; Chan, Kin-Fai; So, Pui-Kin; He, Dandan; Chan, Edward Wai-chi; Chan, Tak-hang; Wong, Kwok-yin; Tao, Jiang; Chen, Sheng
• Is Part Of: Chemical communications. Volume 51:Issue 46(2015)
• Page Start: 9543
• Page End: 9546
• Publication Date: 2015-06-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc02594j
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjqwgskmb" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We identified a potent NDM-1 inhibitor that formed a S–Se bond with the Cys²²¹ residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.</p> </abstract>