Bioorthogonal SERS Nanoprobes for Mulitplex Spectroscopic Detection, Tumor Cell Targeting, and Tissue Imaging. Issue 37 (23rd July 2015)

• Record Type: Journal Article
• Authors: Wu, Junzhou; Liang, Duanwei; Jin, Qingqing; Liu, Jie; Zheng, Meiling; Duan, Xuanming; Tang, Xinjing
• Is Part Of: Chemistry. Volume 21:Issue 37(2015)
• Page Start: 12914
• Page End: 12918
• Publication Date: 2015-07-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501942
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A surface‐enhanced Raman scattering (SERS) technique shows extraordinary features for a range of biological and biomedical applications. Herein, a series of novel bioorthogonal SERS nanoprobes were constructed with Gold nanoflower (AuNF) and Raman reporters, the signals of which were located in a Raman‐silent region of biological samples. AS1411 aptamer was also co‐conjugated with AuNF through a self‐assembled monolayer coverage strategy. Multiplex SERS imaging using these nanoprobes with three different bioorthogonal small‐molecule Raman reporters is successfully achieved with high multiplexing capacity in a biologically Raman‐silent region. These Raman nanoprobes co‐conjugated with AS1411 showed high affinity for tumor cells with overexpressed nucleolin and can be used for selective tumor cell screening and tissue imaging.</p> </abstract>