BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes1. Issue 37 (23rd July 2015)

• Record Type: Journal Article
• Authors: Lhenry, Damien; Larrouy, Manuel; Bernhard, Claire; Goncalves, Victor; Raguin, Olivier; Provent, Peggy; Moreau, Mathieu; Collin, Bertrand; Oudot, Alexandra; Vrigneaud, Jean‐Marc; Brunotte, François; Goze, Christine; Denat, Franck
• Is Part Of: Chemistry. Volume 21:Issue 37(2015)
• Page Start: 13091
• Page End: 13099
• Publication Date: 2015-07-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501676
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual‐labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with ¹¹¹In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY‐based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent.</p> </abstract>