Inside Cover: 4‐Alkylated Silver–N‐Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells (ChemMedChem 9/2015). Issue 9 (18th August 2015)

• Record Type: Journal Article
• Authors: Sandtorv, Alexander H.; Leitch, Calum; Bedringaas, Siv Lise; Gjertsen, Bjørn Tore; Bjørsvik, Hans‐René
• Is Part Of: ChemMedChem. Volume 10:Issue 9(2015:Sep.)
• Page Start: 1450
• Page End: 1450
• Publication Date: 2015-08-18
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201500344
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> two silver–N‐heterocyclic carbene (NHC) complexes with different alkyl side chains at the 4‐position, namely NHC‐1 (methyl, orange) and NHC‐2 (heptyl, green). To accomplish the devised de novo total synthesis, we utilized novel and indispensable synthetic methods recently developed by our group. Both complexes exhibited potent cytotoxicity against two human leukemia cell lines, HL60 (shown) and MOLM‐13, in the micromolar range. More details can be found in the Full Paper by H.‐R. Bjørsvik et al. on <bold>page 1522 in Issue 9, 2015</bold>. (DOI: <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">10.1002/cmdc.201500234</ext-link>).<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2gd40835" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>