The effect of caffeine and albuterol on body composition and metabolic rate. (4th August 2015)

• Record Type: Journal Article
• Authors: Liu, Ann G.; Arceneaux, Kenneth P.; Chu, Jessica T.; Jacob, Gregory; Schreiber, Allyson L.; Tipton, Russell C.; Yu, Ying; Johnson, William D.; Greenway, Frank L.; Primeaux, Stefany D.
• Is Part Of: Obesity. Volume 23:Number 9(2015:Sep.)
• Page Start: 1830
• Page End: 1835
• Publication Date: 2015-08-04
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21163
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21163-sec-0001" sec-type="section"> <title>Objective</title> <p>Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.</p> </sec> <sec id="oby21163-sec-0002" sec-type="section"> <title>Methods</title> <p>In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.</p> </sec> <sec id="oby21163-sec-0003" sec-type="section"> <title>Results</title> <p>Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer‐term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.</p> </sec> <sec id="oby21163-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4‐8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.</p> </sec> </abstract>