Synthesis, Spectroscopy, Semi‐empirical and Biological Activities of Organotin(IV) Complexes with o‐Isopropyl Carbonodithioic Acid. Issue 8 (14th August 2015)

• Record Type: Journal Article
• Authors: Javed, Fatima; Ali, Saqib; Shahzadi, Saira; Khalid, Nasir; Tabassum, Saira; Khan, Imran; Sharma, Saroj K.; Qanungo, Kushal
• Is Part Of: Journal of the Chinese Chemical Society. Volume 62:Issue 8(2015:Aug.)
• Page Start: 728
• Page End: 738
• Publication Date: 2015-08-14
• Subjects: Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.201500235
• Languages: English
• ISSNs: 0009-4536

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>New organotin(IV) complexes have been synthesized by treating potassium <italic>o</italic>‐isopropyl carbonodithioate with R₂SnCl₂/R₃SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR (¹H, ¹³C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi‐empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex <bold>5</bold> is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex <bold>5</bold> exhibits higher binding constant as compared to complex <bold>3</bold>. In protein kinase inhibition assay, compound <bold>3</bold> was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes.</p> </abstract>