<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In the presence of cinchona‐thiourea organocatalyst, the enantioselective three‐component cascade reaction of isatins, malononitrile, and 2‐hydroxynaphthalene‐1, 4‐diones proceeds readily to furnish chiral pyranonaphthoquinone‐fused spirooxindoles.</p> </abstract>