Dual‐Wavelength Irradiation and Dox Delivery for ­Cancer Cell Ablation with Photocatalytic Pr Doped TiO2/NGO ­Hybrid Nanocomposite. Issue 12 (17th June 2015)

• Record Type: Journal Article
• Authors: Jang, Hongje; Choi, Myung‐Ho; Yim, Yeajee; Kim, Young‐Kwan; Min, Dal‐Hee
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 12(2015)
• Page Start: 1833
• Page End: 1840
• Publication Date: 2015-06-17
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500157
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Herein, hybrid nanocomposite of praseodymium doped TiO₂ nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As‐synthesized Pr‐TiO₂/NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO₂. Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near‐infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.</p> </abstract>