Effect of multivitamin versus multivitamin-mineral supplementation on metabolic profiles and biomarkers of oxidative stress in pregnant women: a double-blind randomized clinical trial. (July 2015)

• Record Type: Journal Article
• Authors: Taghizadeh, Mohsen; Samimi, Mansooreh; Kolahdooz, Fariba; Tabassi, Zohreh; Jamilian, Mehri; Asemi, Zatollah
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 11(2015)
• Page Start: 1336
• Page End: 1342
• Publication Date: 2015-07
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: This study was designed to determine the favorable effects of received multivitamin versus multivitamin-mineral supplements on metabolic profiles and biomarkers of oxidative stress among Iranian pregnant women.</p> <p> <italic>Methods</italic>: This double-blind randomized-controlled clinical trial was conducted among 70 pregnant women, primigravida, aged 18–35 years old between 16 and 37 weeks gestation. Subjects were randomly assigned to receive either the multivitamin (<italic>n = </italic>35) or multivitamin-mineral supplements (<italic>n = </italic>35) for 20 weeks. Fasting blood samples were taken at baseline and after a 20-week intervention to measure lipid profiles and biomarkers of oxidative stress.</p> <p> <italic>Results</italic>: After 20 weeks of intervention, multivitamin-mineral supplementation resulted in a significant difference on serum triglycerides levels (changes from baseline in multivitamin-mineral group: +6.1 versus in multivitamin group: +45.9 mg/dl, <italic>p</italic> = 0.04) compared with the multivitamin group. In addition, increased concentrations of serum HDL-cholesterol (changes from baseline in multivitamin-mineral group: +0.1 versus in multivitamin group: −7.4 mg/dl, <italic>p</italic> = 0.02) and total glutathione (GSH) levels (changes from baseline in multivitamin-mineral group: +151.09 versus in multivitamin group: −116.21 µmol/l, <italic>p</italic> = 0.003) were also seen in the multivitamin-mineral group compared with the multivitamin group.</p> <p> <italic>Conclusion</italic>: Supplementation of multivitamin-mineral compared to multivitamin supplementation for 20 weeks during pregnancy had beneficial effects on triglycerides, HDL-cholesterol and GSH levels.</p> </abstract>