Salivary progesterone and cervical length measurement as predictors of spontaneous preterm birth. (July 2015)

• Record Type: Journal Article
• Authors: Maged, Ahmed M.; Mohesen, Mohamed; Elhalwagy, Ahmed; Abdelhafiz, Ali
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 10(2015)
• Page Start: 1147
• Page End: 1151
• Publication Date: 2015-07
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To evaluate the efficacy of salivary progesterone, cervical length measurement in predicting preterm birth (PTB).</p> <p> <italic>Methods</italic>: Prospective observational study included 240 pregnant women with gestational age (GA) 26–34 weeks classified into two equal groups; group one are high risk for PTB (those with symptoms of uterine contractions or history of one or more spontaneous preterm delivery or second trimester abortion) and group 2 are controls.</p> <p> <italic>Results</italic>: There was a highly significant difference between the two study groups regarding GA at delivery (31.3 ± 3.75 in high risk versus 38.5 ± 1.3 in control), cervical length measured by transvaginal ultrasound (24.7 ± 8.6 in high risk versus 40.1 ± 4.67 in control) and salivary progesterone level (728.9 ± 222.3 in high risk versus 1099.9 ± 189.4 in control; <italic>p</italic> < 0.001). There was a statistically significant difference between levels of salivary progesterone at different GA among the high risk group (<italic>p</italic> value 0.035) but not in low risk group (<italic>p</italic> value 0.492). CL measurement showed a sensitivity of 71.5% with 100% specificity, 100% PPV, 69.97% NPV and accuracy of 83%, while salivary progesterone showed a sensitivity of 84% with 90% specificity, 89.8% PPV, 85.9% NPV and accuracy of 92.2%.</p> <p> <italic>Conclusion</italic>: The measurement of both salivary progesterone and cervical length are good predictors for development of PTB.</p> </abstract>