The association between rs4684677 T/A polymorphism in preproghrelin gene and predisposition to autoimmune thyroid diseases in children*. (September 2015)

• Record Type: Journal Article
• Authors: Moniuszko, Anna; Wawrusiewicz-Kurylonek, Natalia; Bossowska, Anna; Gościk, Joanna; Łuczyński, Włodzimierz; Głowińska-Olszewska, Barbara; Krętowski, Adam; Bossowski, Artur
• Is Part Of: Autoimmunity. Volume 48:Number 6(2015)
• Page Start: 418
• Page End: 422
• Publication Date: 2015-09
• Subjects: Autoimmunity -- Periodicals; Autoimmune diseases -- Periodicals; 571.973
• Languages: English
• ISSNs: 0891-6934

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: A potential role of preproghrelin polymorphisms on autoimmune thyroid diseases (AITDs) has not been established equivocally yet. <italic>Aim</italic>: To estimate the association of two polymorphisms of preproghrelin gene with the predisposition to Graves' disease (GD) and Hashimoto's thyroiditis (HT) in children. <italic>Methods</italic>: The study was performed in 145 patients with GD, 87 with HT and 161 healthy volunteers. The two single nucleotide polymorphisms (SNPs) rs696217 (C_3151003_20) and rs4684677 (C_25607748_10) in the preproghrelin gene were genotyped by TaqMan SNP genotyping assay using the real-time PCR. <italic>Results</italic>: Rs4684677 T alleles were more frequent in HT patients (99% in women and 100% in men) in comparison to healthy subjects (<italic>p</italic> = 0.002) with OR = 8.0 and 95% confidence interval for OR: 1.8–206.7. In women group, rs4684677 T alleles were more frequent compared to healthy controls (99%) in HT (<italic>p</italic> = 0.02) with OR = 6.7 and 95% confidence interval for OR: 1.2–168.37. Frequency of the SNP rs696217 did not differ between the groups. There was a significant relationship between rs696217 polymorphisms and anti-TSHR antibodies level (<italic>p</italic> = 0.036) in women from GD/HT groups. A significant relationship between rs696217 polymorphisms and anti-TG antibodies level in GD women group (<italic>p</italic> = 0.038) and between rs696217 polymorphisms and fT4 concentration (<italic>p</italic> = 0.03) were found. <italic>Conclusions</italic>: Rs4684677 T/A polymorphisms in preproghrelin gene could contribute to development of AITDs in children and T allele is the main risk factor.</p> </abstract>