Current and future molecular diagnostics in non-small-cell lung cancer. (August 2015)
- Record Type:
- Journal Article
- Title:
- Current and future molecular diagnostics in non-small-cell lung cancer. (August 2015)
- Main Title:
- Current and future molecular diagnostics in non-small-cell lung cancer
- Authors:
- Li, Chun Man
Chu, Wing Ying
Wong, Di Lun
Tsang, Hin Fung
Tsui, Nancy Bo Yin
Chan, Charles Ming Lok
Xue, Vivian Wei Wen
Siu, Parco Ming Fai
Yung, Benjamin Yat Ming
Chan, Lawrence Wing Chi
Wong, Sze Chuen Cesar - Abstract:
- <abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>The molecular investigation of lung cancer has opened up an advanced area for the diagnosis and therapeutic management of lung cancer patients. Gene alterations in cancer initiation and progression provide not only information on molecular changes in lung cancer but also opportunities in advanced therapeutic regime by personalized targeted therapy. <italic>EGFR</italic> mutations and <italic>ALK</italic> rearrangement are important predictive biomarkers for the efficiency of tyrosine kinase inhibitor treatment in lung cancer patients. Moreover, epigenetic aberration and microRNA dysregulation are recent advances in the early detection and monitoring of lung cancer. Although a wide range of molecular tests are available, standardization and validation of assay protocols are essential for the quality of the test outcome. In this review, current and new advancements of molecular biomarkers for non-small-cell lung cancer will be discussed. Recommendations on future development of molecular diagnostic services will also be explored.</p> </abstract>
- Is Part Of:
- Expert review of molecular diagnostics. Volume 15:Number 8(2015)
- Journal:
- Expert review of molecular diagnostics
- Issue:
- Volume 15:Number 8(2015)
- Issue Display:
- Volume 15, Issue 8 (2015)
- Year:
- 2015
- Volume:
- 15
- Issue:
- 8
- Issue Sort Value:
- 2015-0015-0008-0000
- Page Start:
- 1061
- Page End:
- 1074
- Publication Date:
- 2015-08
- Subjects:
- Molecular diagnosis -- Periodicals
616.0758205 - Journal URLs:
- http://informahealthcare.com/toc/ero/current ↗
http://www.future-drugs.com/loi/erm ↗
http://www.tandfonline.com/toc/iero20/current ↗
http://informahealthcare.com ↗ - DOI:
- 10.1586/14737159.2015.1063420 ↗
- Languages:
- English
- ISSNs:
- 1473-7159
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3842.002987
British Library DSC - BLDSS-3PM
British Library HMNTS - Digital store
British Library HMNTS - ELD Digital store - Ingest File:
- 4080.xml