NMR Signal Enhancement by Effective SABRE Labeling of Oligopeptides. Issue 36 (17th July 2015)

• Record Type: Journal Article
• Authors: Ratajczyk, Tomasz; Gutmann, Torsten; Bernatowicz, Piotr; Buntkowsky, Gerd; Frydel, Jaroslaw; Fedorczyk, Bartlomiej
• Is Part Of: Chemistry. Volume 21:Issue 36(2015)
• Page Start: 12616
• Page End: 12619
• Publication Date: 2015-07-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501552
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Signal amplification by reversible exchange (SABRE) can enhance nuclear magnetic resonance signals by several orders of magnitude. However, until now this was limited to a small number of model target molecules. Here, a new convenient method for SABRE activation applicable to a variety of synthetic model oligopeptides is demonstrated. For the first time, a highly SABRE‐active pyridine‐based biocompatible molecular framework is incorporated into synthetic oligopeptides. The SABRE activity is preserved, demonstrating the importance of such earmarking. Finally, a crucial exchange process responsible for SABRE activity is identified and discussed.</p> </abstract>