A stable bidentate protein binder achieved via DNA self-assembly driven ligand migration1. Issue 71 (14th September 2015)

• Record Type: Journal Article
• Authors: Su, Xiaoye; Zhou, Xiao; Zhang, Nan; Zhu, Mengyuan; Zhang, Hong; Jayawickramarajah, Janarthanan
• Is Part Of: Chemical communications. Volume 51:Issue 71(2015)
• Page Start: 13615
• Page End: 13618
• Publication Date: 2015-09-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc03213j
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2g30djgn" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />DNA-templated ligand migration, involving the transfer of a binding head-group, leads to the conversion of a low-affinity human serum albumin binder (1) to a high affinity bidentate binder (2). Further, the activated binder remains effective despite denaturation (3) and degradation (4).</p> </abstract>