Hepatic lipid droplet biology: Getting to the root of fatty liver. Issue 3 (9th May 2015)

• Record Type: Journal Article
• Authors: Mashek, Douglas G.; Khan, Salmaan A.; Sathyanarayan, Aishwarya; Ploeger, Jonathan M.; Franklin, Mallory P.
• Is Part Of: Hepatology. Volume 62:Issue 3(2015:Sep.)
• Page Start: 964
• Page End: 967
• Publication Date: 2015-05-09
• Subjects: Heart -- Diseases -- Nursing -- Periodicals; Lungs -- Diseases -- Nursing -- Periodicals; Intensive care nursing -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1002/hep.27839
• Languages: English
• ISSNs: 0270-9139

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease. (H<sc>epatology</sc> 2015;62:964–967)</p> </abstract>