Cationic Rhodium(III)‐Catalyzed Direct C‐2 Carboxamidation of Indoles with Isocyanates via CH Bond Functionalization. Issue 12 (18th August 2015)

• Record Type: Journal Article
• Authors: Xu, Jun; Sharma, Nandini; Sharma, Upendra K.; Li, Zhenghua; Song, Gonghua; Van der Eycken, Erik V.
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 12(2015)
• Page Start: 2615
• Page End: 2621
• Publication Date: 2015-08-18
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500109
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A pentamethylcyclopentadienylrhodium(III)‐catalyzed regioselective synthesis of indole‐2‐carboxamides is described employing <italic>N</italic>‐pyrimidylindoles and isocyanates as coupling partners <italic>via</italic> CH functionalization. A wide variety of indole‐2‐carboxamides can be synthesized <italic>via</italic> this method under relatively mild conditions with broad functional group tolerance. The effect of various directing group on this transformation was also studied, unveiling the pyrimidyl group as an easily installable and removable directing group.</p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2fzmk9ct" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>