Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐N‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2, 3, 6, 7‐Tetrahydro‐1H‐pyrrolo[3, 2‐c]pyridin‐4(5H)‐ones. Issue 12 (13th August 2015)

• Record Type: Journal Article
• Authors: Zhang, Zhiguo; Zhang, Feisong; Wang, Huanhuan; Wu, Hao; Duan, Xinyu; Liu, Qingfeng; Liu, Tongxin; Zhang, Guisheng
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 12(2015)
• Page Start: 2681
• Page End: 2686
• Publication Date: 2015-08-13
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500251
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A facile one‐pot, catalyst‐free reaction has been developed for the synthesis of 2, 3, 6, 7‐tetrahydro‐1<italic>H</italic>‐pyrrolo[3, 2‐<italic>c</italic>]pyridin‐4(5<italic>H</italic>)‐ones from readily available 1‐acryloyl‐1‐<italic>N</italic>‐arylcarbamylcyclopropanes and amines using a domino ring‐opening/cyclization/aza‐addition sequence. </p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2fzmk7fw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>