Remote ischemic preconditioning does not increase circulating or effector organ concentrations of proopiomelanocortin derivates. (October 2015)

• Record Type: Journal Article
• Authors: Birkelund, Thomas; Obad, Damir Salskov; Matejec, Reginald; Bøtker, Hans Erik; Ravn, Hanne Berg
• Is Part Of: Scandinavian cardiovascular journal. Volume 49:Number 5(2015:Oct.)
• Page Start: 257
• Page End: 263
• Publication Date: 2015-10
• Subjects: Cardiovascular system -- Diseases -- Periodicals; 617.41
• Languages: English
• ISSNs: 1401-7431

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives</italic>. The aim of the present study was to compare changes in circulating levels of proopiomelanocortin (POMC) derivates and lactate after remote ischemic preconditioning (IPC) and physical exercise. <italic>Introduction</italic>. Remote IPC (rIPC) is cardioprotective following acute myocardial infarction and major cardiac surgery. A blood-borne, transferable factor, released following not only rIPC but also vigorous exercise, mediates protection that is abolished by naloxone suggesting involvement of an opioid-receptor-dependent pathway. <italic>Design</italic>. Eight healthy volunteers underwent rIPC by four cycles of 5-min inflation of a pneumatic tourniquet to 200 mmHg interrupted by 5 min of deflation. Subsequently, circulating plasma levels of POMC derivates, cortisol, and lactate were measured. After 3 days, the volunteers completed a vigorous exercise program, after which the same compounds were measured. <italic>Results</italic>. While rIPC was not associated with any significant increase in circulating POMC derivates or lactate, exercise induced significant elevation of both compared with baseline. <italic>Conclusions</italic>. We were not able to demonstrate a detectable increase in circulating POMC derivates by a standard rIPC stimulus, suggesting that rIPC effect is not mediated by local or detectable central release of these derivates.</p> </abstract>