Residential radon and lung cancer characteristics in never smokers. (August 2015)

• Record Type: Journal Article
• Authors: Torres-Durán, María; Ruano-Ravina, Alberto; Parente-Lamelas, Isaura; Leiro-Fernández, Virginia; Abal-Arca, José; Montero-Martínez, Carmen; Pena-Álvarez, Carolina; Castro-Añón, Olalla; Golpe-Gómez, Antonio; Martínez, Cristina; Guzmán-Taveras, Rosirys; Mejuto-Martí, María José; Provencio, Mariano; Fernández-Villar, Alberto; Barros-Dios, Juan Miguel
• Is Part Of: International journal of radiation biology. Volume 91:Number 8(2015:Aug.)
• Page Start: 605
• Page End: 610
• Publication Date: 2015-08
• Subjects: Radiation -- Physiological effect -- Periodicals; Radiobiology -- Periodicals; 571.45
• Languages: English
• ISSNs: 0955-3002

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis.</p> <p> <italic>Materials and methods</italic>: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements.</p> <p> <italic>Results</italic>: Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44–3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases.</p> <p> <italic>Conclusions</italic>: Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.</p> </abstract>