Renal medullary carcinoma and sickle cell trait: A systematic review. Issue 10 (5th June 2015)

• Record Type: Journal Article
• Authors: Alvarez, Ofelia; Rodriguez, Maria M.; Jordan, Lanetta; Sarnaik, Sharada
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 10(2015:Oct.)
• Page Start: 1694
• Page End: 1699
• Publication Date: 2015-06-05
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25592
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25592-sec-0001" sec-type="section"> <p>Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N = 217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor‐related mortality was 95%. Four non‐metastatic patients were long‐term disease‐free survivors. Although risk appears to be very low<underline>, </underline> individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation. Pediatr Blood Cancer 2015;62:1694–1699. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>