Differences in survival outcome between stage I and stage II glottic cancer: A SEER‐based analysis. (24th June 2015)

• Record Type: Journal Article
• Authors: Chen, Jonathan J.; Stessin, Alexander; Christos, Paul; Wernicke, A. Gabriella; Nori, Dattatreyudu; Parashar, Bhupesh
• Is Part Of: Laryngoscope. Volume 125:Number 9(2015:Sep.)
• Page Start: 2093
• Page End: 2098
• Publication Date: 2015-06-24
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.25338
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary25338-sec-0001" sec-type="section"> <title>Objective</title> <p>The purpose of this study was to investigate and compare the cause‐specific survival (CSS) of stage I (tumor [T]1 node [N]0 metastasis [M]0) versus stage II (T2N0M0) glottic cancer in a large population cohort.</p> </sec> <sec id="lary25338-sec-0002" sec-type="section"> <title>Study Design</title> <p>We analyzed data from the Surveillance, Epidemiology, and End Results 18 database from 1973 to 2009, comprising patients diagnosed with T1N0M0 or T2N0M0 squamous cell glottic cancer. Kaplan‐Meier survival analysis, multivariable Cox proportional hazards regression analysis, and competing‐risks survival regression were used for statistical analysis.</p> </sec> <sec id="lary25338-sec-0003" sec-type="section"> <title>Results</title> <p>There were 4, 422 patients who met all inclusion criteria. The 36‐month CSS was 93.9% for stage I verus 86.5% for stage II, with <italic>P</italic> < 0.0001. Stage II status conferred a 2.494 hazard ratio for increased risk of cause‐specific death compared to stage I.</p> </sec> <sec id="lary25338-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Stage II glottic cancers have a significantly worse prognosis and may need a different approach to management than stage I tumors.</p> </sec> <sec id="lary25338-sec-0005" sec-type="section"> <title>Level of Evidence</title> <p>4. <italic>Laryngoscope</italic>, 125:2093–2098, 2015</p> </sec> </abstract>