MicroRNA‐34c‐5p is related to recurrence in laryngeal squamous cell carcinoma. (7th July 2015)

• Record Type: Journal Article
• Authors: Re, Massimo; Çeka, Artan; Rubini, Corrado; Ferrante, Luigi; Zizzi, Antonio; Gioacchini, Federico M.; Tulli, Michele; Spazzafumo, Liana; Sellari‐Franceschini, Stefano; Procopio, Antonio D.; Olivieri, Fabiola
• Is Part Of: Laryngoscope. Volume 125:Number 9(2015:Sep.)
• Page Start: E306
• Page End: E312
• Publication Date: 2015-07-07
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.25475
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary25475-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC‐related miR‐34c‐5p with disease‐free survival and overall survival.</p> </sec> <sec id="lary25475-sec-0002" sec-type="section"> <title>Study Design</title> <p>Retrospective cohort study.</p> </sec> <sec id="lary25475-sec-0003" sec-type="section"> <title>Methods</title> <p>Expression levels of miR‐34c‐5p were detected in 90 LSCC formalin‐fixed paraffin‐embedded tissues by reverse‐transcription quantitative polymerase chain reaction. Overall survival and disease‐free survival were evaluated using the Kaplan‐Meier method, and multivariate analysis was performed using Cox proportional hazard analysis.</p> </sec> <sec id="lary25475-sec-0004" sec-type="section"> <title>Results</title> <p>A downregulation of miR‐34c‐5p expression significantly correlated with worse disease‐free and overall survival. In the multivariate analysis, low miR‐34c‐5p expression was associated with an increased risk of recurrence.</p> </sec> <sec id="lary25475-sec-0005" sec-type="section"> <title>Conclusions</title> <p>A downregulation of miR‐34c‐5p in LSCC is independently associated with unfavorable disease‐free survival, suggesting that miR‐34c‐5p might be a promising marker for evaluating the risk of recurrences.</p> </sec> <sec id="lary25475-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>NA <italic>Laryngoscope</italic>, 125:E306–E312, 2015</p> </sec> </abstract>