An academic, clinical and industrial update on electrospun, additive manufactured and imprinted medical devices. (September 2015)

• Record Type: Journal Article
• Authors: Ryan, Christina NM; Fuller, Kieran P; Larrañaga, Aitor; Biggs, Manus; Bayon, Yves; Sarasua, Jose R; Pandit, Abhay; Zeugolis, Dimitrios I
• Is Part Of: Expert review of medical devices. Volume 12:Number 5(2015)
• Page Start: 601
• Page End: 612
• Publication Date: 2015-09
• Subjects: Medical instruments and apparatus -- Periodicals; 610.28
• Languages: English
• ISSNs: 1743-4440

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Electrospinning, additive manufacturing and imprint lithography scaffold fabrication technologies have attracted great attention in biomedicine, as they allow production of two- and three- dimensional constructs with tuneable topographical and geometrical features. <italic>In vitro</italic> data demonstrate that electrospun and imprinted substrates offer control over permanently differentiated and stem cell function. Advancements in functionalisation strategies have further enhanced the bioactivity and reparative capacity of electrospun and additive manufactured devices, as has been evidenced in several preclinical models. Despite this overwhelming success in academic setting, only a few technologies have reached the clinic and only a fraction of them have become commercially available products.</p> </abstract>