Three‐dimensional whole‐heart T2 mapping at 3T. Issue 3 (19th September 2014)

• Record Type: Journal Article
• Authors: Ding, Haiyan; Fernandez‐de‐Manuel, Laura; Schär, Michael; Schuleri, Karl H.; Halperin, Henry; He, Le; Zviman, M. Muz; Beinart, Roy; Herzka, Daniel A.
• Is Part Of: Magnetic resonance in medicine. Volume 74:Issue 3(2015:Sep.)
• Page Start: 803
• Page End: 816
• Publication Date: 2014-09-19
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25458
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25458-sec-0001" sec-type="section"> <title>Purpose</title> <p>Detecting variations in myocardial water content with T<sub>2</sub> mapping is superior to conventional T<sub>2</sub>‐weighted MRI since quantification enables direct observation of complicated pathology. Most commonly used T<sub>2</sub> mapping techniques are limited in achievable spatial and/or temporal resolution, both of which reduce accuracy due to partial‐volume averaging and misregistration between images. The goal of this study was to validate a novel free breathing T<sub>2</sub> mapping sequence that overcomes these limitations.</p> </sec> <sec id="mrm25458-sec-0002" sec-type="section"> <title>Methods</title> <p>The proposed technique was made insensitive to heart rate variability through the use of a saturation prepulse to reset magnetization every heartbeat. Respiratory navigator‐gated, differentially T<sub>2</sub>‐weighted volumes were interleaved per heartbeat, guaranteeing registered images and robust voxel‐by‐voxel T<sub>2</sub> maps. Free breathing acquisitions removed limits on spatial resolution and allowed short diastolic windows. Accuracy was quantified with simulations and phantoms.</p> </sec> <sec id="mrm25458-sec-0003" sec-type="section"> <title>Results</title> <p>Homogeneous three‐dimensional (3D) T<sub>2</sub> maps were obtained from normal human subjects and swine. Normal human and swine left ventricular T<sub>2</sub> values were 42.3 ± 4.0 and 43.5 ± 4.3 ms, respectively. The T<sub>2</sub> value for edematous myocardium obtained from a swine model of acute myocardial infarction was 59.1 ± 7.1 ms.</p> </sec> <sec id="mrm25458-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Free‐breathing accurate 3D T<sub>2</sub> mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T<sub>2</sub>‐weighted techniques. Magn Reson Med 74:803–816, 2015. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>