ZFIN, The zebrafish model organism database: Updates and new directions. Issue 8 (8th July 2015)

• Record Type: Journal Article
• Authors: Ruzicka, Leyla; Bradford, Yvonne M.; Frazer, Ken; Howe, Douglas G.; Paddock, Holly; Ramachandran, Sridhar; Singer, Amy; Toro, Sabrina; Van Slyke, Ceri E.; Eagle, Anne E.; Fashena, David; Kalita, Patrick; Knight, Jonathan; Mani, Prita; Martin, Ryan; Moxon, Sierra A.T.; Pich, Christian; Schaper, Kevin; Shao, Xiang; Westerfield, Monte; Vize, Peter; Westerfiled, Monte
• Is Part Of: Genesis. Volume 53:Issue 8(2015:Aug.)
• Page Start: 498
• Page End: 509
• Publication Date: 2015-07-08
• Subjects: Developmental genetics -- Periodicals; Genetics -- Periodicals; Developmental biology -- Periodicals; Embryology -- Periodicals; Genetic regulation -- Periodicals; 576.5
• DOI: 10.1002/dvg.22868
• Languages: English
• ISSNs: 1526-954X

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>The Zebrafish Model Organism Database (ZFIN; <ext-link ext-link-type="uri" xlink:href="http://zfin.org" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">http://zfin.org</ext-link>) is the central resource for genetic and genomic data from zebrafish (<italic>Danio rerio</italic>) research. ZFIN staff curate detailed information about genes, mutants, genotypes, reporter lines, sequences, constructs, antibodies, knockdown reagents, expression patterns, phenotypes, gene product function, and orthology from publications. Researchers can submit mutant, transgenic, expression, and phenotype data directly to ZFIN and use the ZFIN Community Wiki to share antibody and protocol information. Data can be accessed through topic‐specific searches, a new site‐wide search, and the data‐mining resource ZebrafishMine (<ext-link ext-link-type="uri" xlink:href="http://zebrafishmine.org" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">http://zebrafishmine.org</ext-link>). Data download and web service options are also available. ZFIN collaborates with major bioinformatics organizations to verify and integrate genomic sequence data, provide nomenclature support, establish reciprocal links, and participate in the development of standardized structured vocabularies (ontologies) used for data annotation and searching. ZFIN‐curated gene, function, expression, and phenotype data are available for comparative exploration at several multi‐species resources. The use of zebrafish as a model for human disease is increasing. ZFIN is supporting this growing area with three major projects: adding easy access to computed orthology data from gene pages, curating details of the gene expression pattern changes in mutant fish, and curating zebrafish models of human diseases. genesis 53:498–509, 2015. © 2015 Wiley Periodicals, Inc.</p> </abstract>