Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration. (September 2015)

• Record Type: Journal Article
• Authors: Waidyanatha, Suramya; Mathews, James M.; Patel, Purvi R.; Black, Sherry R.; Snyder, Rodney W.; Fennell, Timothy R.
• Is Part Of: Xenobiotica. Volume 45:Number 9(2015:Sep.)
• Page Start: 811
• Page End: 819
• Publication Date: 2015-09
• Subjects: Metabolism -- Periodicals; Drugs -- Physiological effect -- Periodicals; Food additives -- Periodicals; Chemicals -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; Metabolism -- Periodicals; 574.133
• Languages: English
• ISSNs: 0049-8254

Abstract

<abstract> <title>Abstract</title> <p>1. Bisphenol AF (BPAF) is used as a crosslinking agent for polymers and is being considered as a replacement for bisphenol A (BPA).</p> <p>2. In this study, comparative clearance and metabolism of BPAF and BPA in hepatocytes and the disposition and metabolism of BPAF in rodents following oral administration of 3.4, 34 or 340 mg/kg [¹⁴C]BPAF were investigated.</p> <p>3. BPAF was cleared more slowly than BPA in hepatocytes with the rate: rat &gt; mouse &gt; human.</p> <p>4. [¹⁴C]BPAF was excreted primarily in feces by 72 h after oral administration to rats (65–80%) and mice (63–72%). Females excreted more in urine (rat, 15%; mouse, 24%) than males (rat, 1–4%; mouse, 10%). Residual tissue radioactivity was &lt;2% of the dose at 72 h. Similar results were observed following intravenous administration.</p> <p>5. In male rats, 52% of a 340 mg/kg oral dose was excreted in 24 h bile and was mostly comprised of BPAF glucuronide. However, &gt;94% of fecal radioactivity was present as BPAF, suggesting extensive deconjugation in the intestine.</p> <p>6. Metabolites identified in bile were BPAF-glucuronide, -diglucuronide, -glucuronide sulfate and -sulfate.</p> <p>7. In conclusion, BPAF was well absorbed following gavage administration and highly metabolized and excreted mostly in the feces as BPAF.</p> </abstract>