Hepatitis From Spiroplasma sp. in an Immunocompromised Patient. Issue 9 (1st April 2015)

• Record Type: Journal Article
• Authors: Mueller, N. J.; Tini, G. M.; Weber, A.; Gaspert, A.; Husmann, L.; Bloemberg, G.; Boehler, A.; Benden, C.
• Is Part Of: American journal of transplantation. Volume 15:Issue 9(2015:Sep.)
• Page Start: 2511
• Page End: 2516
• Publication Date: 2015-04-01
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.13254
• Languages: English
• ISSNs: 1600-6135

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ajt13254-sec-0001" sec-type="section"> <p>A 70‐year‐old lung transplant recipient patient was admitted with fever, nausea, abdominal pain, peripheral edema and pronounced weakness. An initial work‐up for presumed infection revealed cholestatic hepatitis, leukocytosis and thrombocytopenia, but failed to detect a pathogen. An increased glucose uptake exclusively in the liver was demonstrated by positron emission tomography. Liver biopsy showed basophilic inclusions in the cytoplasm of hepatocytes. Broad‐ range 16S rRNA gene PCR followed by sequence analysis yielded <italic>Spiroplasma</italic> sp. in two independent blood samples and the liver biopsy, confirming <italic>Spiroplasma</italic> sp. as the causative agent. Antibiotic treatment with doxycycline and azithromycin led to complete recovery.</p> </sec> </abstract>