Preparation and evaluation of a buflomedil hydrochloride niosomal patch for transdermal delivery. (September 2015)

• Record Type: Journal Article
• Authors: Akhtar, Nida; Arkvanshi, Seema; Bhattacharya, Shiv Sankar; Verma, Anurag; Pathak, Kamla
• Is Part Of: Journal of liposome research. Volume 25:Number 3(2015)
• Page Start: 191
• Page End: 201
• Publication Date: 2015-09
• Subjects: Liposomes -- Periodicals; Liposomes -- Periodicals; 575.57
• Languages: English
• ISSNs: 0898-2104

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery.</p> <p> <italic>Objective</italic>: The present research work was aimed to develop niosomal-based transdermal buflomedil hydrochloride patch containing a stable formulation with improved drug permeation.</p> <p> <italic>Materials and methods</italic>: Niosomes were prepared by solvent evaporation method using 3<sup>2</sup> factorial design. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. Optimized niosomal and liposomal formulation were loaded into a patch system. All the patches were then characterized for drug–excipient interaction study, scanning electron microscopy, pharmacotechnical properties and <italic>in vitro</italic> permeation studies.</p> <p> <italic>Result</italic>: F9 formulation having optimum vesicle size (10.09 ± 1.2 µm), highest zeta potential (−85.4 ± 0.56 mV) and maximum percent entrapment efficiency (97.09 ± 0.11%) was selected as optimized formulation. In case of liposomes, formulation F12 was selected. Patches loaded with niosomes showed 95.12 ± 1.19% cumulative amount of drug permeated as compared to liposomal vesicle-loaded patches which showed 82.21 ± 1.24% and control patches 70.10 ± 1.33%. <italic>Discussion</italic>: Flux, permeation rate and permeability coefficient were found to be higher in case of niosomal patches as compared to liposomal patches and control patches. Surfactant present in niosomes act as a penetration enhancer which contribute in the permeation enhancement of buflomedil hydrochloride from niosomes.</p> <p> <italic>Conclusion</italic>: Thus, it was concluded that niosomal vesicles represented to be an efficient and stable vesicular carrier for transdermal delivery of buflomedil hydrochloride.</p> </abstract>