Advanced oxidation protein products in predicting acute kidney injury following cardiac surgery. (May 2015)

• Record Type: Journal Article
• Authors: Du, Song-lin; Zeng, Xiang-zhen; Tian, Jian-wei; Ai, Jun; Wan, Jun; He, Jian-xing
• Is Part Of: Biomarkers. Volume 20:Number 3(2015)
• Page Start: 206
• Page End: 211
• Publication Date: 2015-05
• Subjects: Biochemical markers -- Periodicals; 610.28
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed a prospective cohort study. Thirty-five (22.3%) patients developed AKI, and 32 age- and gender-matched patients without AKI were selected as control. Serum AOPP 1 h after CPB were significantly higher among AKI patients compared with non-AKI patients (81.8 ± 18.6 versus 67.4 ± 12.5 μmol/L, <italic>p</italic> &lt; 0.001), with an area under the receiver-operating characteristic (ROC) curve of 0.714. An optimal serum AOPP 1 h after CPB cutoff of 69.9 μmol/L had a sensitivity of 74%, specificity of 63% and a positive predictive value of 68% for predicting AKI. These results demonstrated that serum AOPP might be an early biomarker for AKI after CPB.</p> </abstract>