Chromogranin A levels and mortality in patients with severe sepsis. (May 2015)

• Record Type: Journal Article
• Authors: Hsu, Chih-Hsin; Reyes, Luis F.; Orihuela, Carlos J.; Buitrago, Ricardo; Anzueto, Antonio; Soni, Nilam J.; Levine, Stephanie; Peters, Jay; Hinojosa, Cecilia A.; Aliberti, Stefano; Sibila, Oriol; Rodriguez, Alejandro; Chalmers, James D.; Martin-Loeches, Ignacio; Bordon, Jose; Blanquer, Jose; Sanz, Francisco; Marcos, Pedro J.; Rello, Jordi; Solé-Violán, Jordi; Restrepo, Marcos I.
• Is Part Of: Biomarkers. Volume 20:Number 3(2015)
• Page Start: 171
• Page End: 176
• Publication Date: 2015-05
• Subjects: Biochemical markers -- Periodicals; 610.28
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.</p> <p> <italic>Objective</italic>: Assess association of CgA levels and mortality risk of severely septic patients.</p> <p> <italic>Methods</italic>: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure &lt;48 h.</p> <p> <italic>Results</italic>: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, <italic>p</italic> = 0.01.</p> <p> <italic>Conclusions</italic>: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.</p> </abstract>