The association between tumor necrosis factor‐α‐308 G/A polymorphism and risk for vitiligo: a meta‐analysis. (29th July 2015)

• Record Type: Journal Article
• Authors: Wu, Dongze; Shi, Deshun; Zhu, Xiaoliang
• Is Part Of: International journal of dermatology. Volume 54:Number 9(2015:Sep.)
• Page Start: 1045
• Page End: 1053
• Publication Date: 2015-07-29
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12866
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12866-abs-0001"> <title>Abstract</title> <sec id="ijd12866-sec-0001" sec-type="section"> <title>Background</title> <p>The contribution of tumor necrosis factor‐<italic>α</italic> (TNF‐<italic>α</italic>)‐308 G/A gene polymorphism (rs1800629) to risk for vitiligo is subject to controversy.</p> </sec> <sec id="ijd12866-sec-0002" sec-type="section"> <title>Objectives</title> <p>The fundamental purpose of the present meta‐analysis was to investigate large‐scale evidence to determine the overall association between TNF‐<italic>α</italic>‐308 G/A polymorphism and susceptibility to vitiligo.</p> </sec> <sec id="ijd12866-sec-0003" sec-type="section"> <title>Methods</title> <p>A literature search of the PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure (CNKI) databases was conducted to identify all studies referring to an association between TNF‐<italic>α</italic>‐308 G/A polymorphism and vitiligo published to June 1, 2014. The principal outcome measure for evaluating the strength of the association was the crude odds ratio (OR) along with the corresponding 95% confidence interval (CI). Data were extracted, and statistical analyses were implemented using <sc>stata</sc> Version 12.0.</p> </sec> <sec id="ijd12866-sec-0004" sec-type="section"> <title>Results</title> <p>Data for a total of 1505 vitiligo cases and 2253 controls from five case–control studies concentrating on the association between TNF‐<italic>α</italic>‐308 G/A polymorphism and vitiligo were included in this meta‐analysis. Combined analysis revealed there to be no association between this polymorphism and susceptibility to vitiligo in five genetic models under random‐effects models. A subgroup analysis by clinical type also demonstrated the absence of any association between TNF‐<italic>α</italic>‐308 G/A polymorphism and generalized vitiligo. However, a significant association was detected in the miscellaneous subgroup under the dominant model (fixed‐effects model: OR 5.69, 95% CI 4.70–6.88; <italic>P</italic> = 0.000) and overdominant model (random‐effects model: OR 5.24, 95% CI 2.26–12.17; <italic>P</italic> = 0.000).</p> </sec> <sec id="ijd12866-sec-0005" sec-type="section"> <title>Conclusions</title> <p>This meta‐analysis indicates that TNF‐<italic>α</italic>‐308 G/A polymorphism is not a genetic risk factor for vitiligo.</p> </sec> </abstract>