Development of HPLC Chiral Stationary Phases Based on (+)‐(18‐Crown‐6)‐2, 3, 11, 12‐tetracarboxylic Acid and Their Applications. Issue 9 (3rd August 2015)

• Record Type: Journal Article
• Authors: Hyun, Myung Ho
• Is Part Of: Chirality. Volume 27:Issue 9(2015)
• Page Start: 576
• Page End: 588
• Publication Date: 2015-08-03
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22484
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Crown ether‐based chiral stationary phases (CSPs) have been known to be useful for the resolution of racemic primary amino compounds. In particular, CSPs based on (+)‐(18‐crown‐6)‐2, 3, 11, 12‐tetracarboxylic acid have been reported to be useful for the resolution of secondary amino compounds as well as primary amino compounds. In this article, the process of developing various CSPs based on (+)‐(18‐crown‐6)‐2, 3, 11, 12‐tetracarboxylic acid to improve the <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">chiral recognition</named-content> efficiency and/or the stability of the CSPs and their applications to the resolution of various primary and nonprimary amino compounds are reviewed. <italic>Chirality 27:576</italic>–<italic>588, 2015</italic>. © 2015 Wiley Periodicals, Inc.</p> </abstract>