A dual-emission fluorescence-enhanced probe for imaging copper(ii) ions in lysosomes1. Issue 33 (7th September 2015)

• Record Type: Journal Article
• Authors: Ren, Mingguang; Deng, Beibei; Wang, Jian-Yong; Liu, Zhan-Rong; Lin, Weiying
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 33(2015)
• Page Start: 6746
• Page End: 6752
• Publication Date: 2015-09-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb01184a
• Languages: English
• ISSNs: 2050-750X

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2fgv0rjf" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We have developed the first example of a fluorescence-enhanced and lysosome-targeted Cu²⁺ probe (<bold>Lys-Cu</bold>) with unique dual-channel emissions. Fluorescence imaging shows that <bold>Lys-Cu</bold> is membrane-permeable and suitable for visualization of Cu²⁺ in lysosomes of living cells by dual-channel imaging.</p> </abstract>