High prevalence of vitamin D deficiency and insufficiency in adolescent inpatients diagnosed with eating disorders. Issue 6 (18th August 2014)

• Record Type: Journal Article
• Authors: Modan‐Moses, Dalit; Levy‐Shraga, Yael; Pinhas‐Hamiel, Orit; Kochavi, Brigitte; Enoch‐Levy, Adi; Vered, Iris; Stein, Daniel
• Is Part Of: International journal of eating disorders. Volume 48:Issue 6(2015:Sep.)
• Page Start: 607
• Page End: 614
• Publication Date: 2014-08-18
• Subjects: Appetite disorders -- Periodicals; Ingestion disorders -- Periodicals; Eating disorders -- Periodicals; 616.8526
• DOI: 10.1002/eat.22347
• Languages: English
• ISSNs: 0276-3478

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="eat22347-sec-0001" sec-type="section"> <title>Objective</title> <p>Previous studies assessing vitamin D status in adolescents with eating disorders showed inconsistent results. The aim of the current study was to assess vitamin D status in a large cohort of adolescent inpatients with eating disorders and its relation to bone mineral density (BMD) and depression.</p> </sec> <sec id="eat22347-sec-0002" sec-type="section"> <title>Method</title> <p>25‐Hydroxyvitamin D (25OHD), calcium, phosphorus, and alkaline phosphatase levels as well as BMD and depression were assessed on admission in 87 inpatients (aged 16 ± 2 years, females = 81) with eating disorders [anorexia nervosa (AN) = 64; bulimia nervosa (BN) = 5; eating disorders not otherwise specified‐binge/purge type (EDNOS‐B/P) = 18].</p> </sec> <sec id="eat22347-sec-0003" sec-type="section"> <title>Results</title> <p>Mean 25OHD levels were 24.1 ± 7.5 ng/ml (25.0 ± 7.6, 25.4 ± 9.9, and 22.0 ± 9.9 ng/ml in patients with AB, BN, and EDNOS‐B/P, respectively). Vitamin D deficiency (<15 ng/ml) was found in 7.8% of the patients, and insufficiency (15–20 ng/ml) in 22.2%. Only 16.7% had levels >32 ng/ml, considered optimal by some experts. No associations were found between 25OHD levels and BMD or comorbid depression. 25OHD levels during winter were significantly lower than summer levels (<italic>p</italic> < .001). Mean lumbar spine BMD z‐score in patients with AN and EDNOS‐B/P type was low (−1.5 ± 1.1) and correlated with body mass index standard deviation score (<italic>p</italic> = .03).</p> </sec> <sec id="eat22347-sec-0004" sec-type="section"> <title>Discussion</title> <p>Adolescents with eating disorders show a high prevalence of vitamin D deficiency and insufficiency. Given the risk of osteoporosis in this population, 25OHD levels found in this group may not offer optimal bone protection. Vitamin D levels should be routinely checked and supplementation should be administered as required. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48: 607–614)</p> </sec> </abstract>