Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*‐Weighted Imaging at 7.0 Tesla. Issue 5 (6th February 2015)

• Record Type: Journal Article
• Authors: Yao, Bing; Ikonomidou, Vasiliki N.; Cantor, Fredric K.; Ohayon, Joan M.; Duyn, Jeff; Bagnato, Francesca
• Is Part Of: Journal of neuroimaging. Volume 25:Issue 5(2015)
• Page Start: 799
• Page End: 806
• Publication Date: 2015-02-06
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12193
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="jon12193-sec-0010" sec-type="section"> <title>BACKGROUND AND PURPOSE</title> <p>Postmortem studies in multiple sclerosis (MS) indicate that in some white matter lesions (WM‐Ls), iron is detectable with T<sub>2</sub>*‐weighted (T<sub>2</sub>*‐w), and its reciprocal R<sub>2</sub>* relaxation rate, magnetic resonance imaging (MRI) at 7.0 Tesla (7T). This iron appears as a hyperintense rim in R<sub>2</sub>* images surrounding a hypointense core. We describe how this observation relates to clinical/radiological characteristics of patients, in vivo.</p> </sec> <sec id="jon12193-sec-0020" sec-type="section"> <title>METHODS</title> <p>We imaged 16 MS patients using 3T and 7T scanners. WM‐Ls were identified on T<sub>1</sub>‐w/T<sub>2</sub>‐w 3T‐MRIs. Thereafter, WM‐Ls with a rim of elevated R<sub>2</sub>* at 7T were counted and compared to their appearance on conventional MRIs.</p> </sec> <sec id="jon12193-sec-0030" sec-type="section"> <title>RESULTS</title> <p>We counted 36 WM‐Ls presenting a rim of elevated R<sub>2</sub>* in 10 patients. Twenty‐three (64%) lesions coincided with focal WM‐Ls on T<sub>2</sub>‐w MRIs; 13 (36%) coincided with only portions of larger lesions on T<sub>2</sub>‐w images; and 20 (56%) corresponded to a hypointense chronic black hole. WM‐Ls presenting a rim of elevated R<sub>2</sub>* were seen in both relapsing‐remitting patients with low disability and in those with long‐standing secondary progressive MS.</p> </sec> <sec id="jon12193-sec-0040" sec-type="section"> <title>CONCLUSIONS</title> <p>WM‐Ls with a contour of high R<sub>2</sub>* are present at different MS stages, potentially representing differences in the contribution of iron in MS disease evolution.</p> </sec> </abstract>