Synthesis of Amphiphilic Comb‐Shape Copolymers Via Ring‐Opening Polymerization of a Macromonomer. Issue 16 (14th July 2015)

• Record Type: Journal Article
• Authors: Zhang, Xiaojin; Zhang, Zhenguo; Su, Xin; Dong, Hui; Zhong, Zhenlin; Zhuo, Renxi
• Is Part Of: Macromolecular chemistry and physics. Volume 216:Issue 16(2015:Aug.)
• Page Start: 1712
• Page End: 1717
• Publication Date: 2015-07-14
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201500161
• Languages: English
• ISSNs: 1022-1352

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Amphiphilic comb‐shape copolymers PCL‐<italic>co</italic>‐P(MTC‐mPEG₁₆) (where PCL, MTC, and mPEG refer to poly(ε‐caprolactone), 2‐methyltrimethylene carbonate, and methoxy poly(ethylene glycol), respectively) are synthesized by ring‐opening polymerization of <italic>ε</italic>‐caprolactone and cyclic carbonate‐terminated PEG macromonomer (MTC‐mPEG₁₆) with benzyl alcohol as an initiator and Sn(Oct)₂ as a catalyst. Amphiphilic copolymers PCL‐<italic>co</italic>‐P(MTC‐mPEG₁₆) can form micelles in aqueous solution by self‐assembly. The diameters of PCL‐<italic>co</italic>‐P(MTC‐mPEG₁₆) micelles characterized by dynamic light scattering area few dozens of nanometers with a narrow size distribution and the morphology of the micelles observed through transmission electron microscopy are nanosized spheres. The in vitro drug release of comb‐shape copolymer PCL‐<italic>co</italic>‐P(MTC‐mPEG₁₆) micelles is more stable and sustained than that of linear block copolymers mPEG‐<italic>b</italic>‐PCL. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2f9qhqzx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>