S100A14 is a novel independent prognostic biomarker in the triple‐negative breast cancer subtype. Issue 9 (21st May 2015)

• Record Type: Journal Article
• Authors: Ehmsen, Sidse; Hansen, Lea Tykgaard; Bak, Martin; Brasch‐Andersen, Charlotte; Ditzel, Henrik J; Leth‐Larsen, Rikke
• Is Part Of: International journal of cancer. Volume 137:Issue 9(2015:Nov. 01)
• Page Start: 2093
• Page End: 2103
• Publication Date: 2015-05-21
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.29582
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Triple‐negative breast cancer (TNBC) represents a heterogeneous subgroup with generally poor outcome and lack of an effective targeted therapy. Prognostic or predictive biomarkers to guide treatment decisions for this group of patients are needed. To evaluate the potential of S100A14 protein as a novel biomarker in TNBC, the protein expression of S100A14 was correlated with clinical outcomes in a Pilot Sample set and a Danish cohort of predominantly TNBC patients. Kaplan‐Meier analysis identified a prognostic impact of S100A14 on disease‐free survival and overall survival, showing that tumors with high S100A14 protein expression levels were significantly correlated with poor outcome in TNBC patients (<italic>p =</italic> 0.017; <italic>p =</italic> 0.038), particularly those in the basal‐like subgroup (<italic>p =</italic> 0.006; <italic>p =</italic> 0.037). Importantly, TNBC patients with high S100A14 expression, but tumor‐negative axillary lymph nodes (N−), had equally poor outcomes as those with tumor‐positive axillary lymph nodes (N+), while TNBC/N− patients with low S100A14 expression had a significantly better disease free survival (<italic>p =</italic> 0.013). Multivariate analysis revealed that S100A14 is an independent prognostic factor for TNBC patients (<italic>p =</italic> 0.024; <italic>p =</italic> 0.05). At the cellular level, S100A14 was found to be expressed in epithelial‐like, but not in mesenchymal‐like, TNBC cells <italic>in vitro</italic>. S100A14 is an independent prognostic factor in TNBC and a novel potential therapeutic target in TNBC.</p> </abstract>