Integrated genomic analyses identify KDM1A's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer. Issue 2 (28th October 2015)

• Record Type: Journal Article
• Authors: Narayanan, Sathiya Pandi; Singh, Smriti; Gupta, Amit; Yadav, Sandhya; Singh, Shree Ram; Shukla, Sanjeev
• Is Part Of: Cancer letters. Volume 367:Issue 2(2015)
• Page Start: 162
• Page End: 172
• Publication Date: 2015-10-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.07.022
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Oral cancer is the sixth most common cancer in the developing countries.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Elevated expression of <italic>KDM1A</italic> in oral cancers promotes cell proliferation.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>KDM1A</italic> knockdown decreases E2F signaling in oral cancer cell lines.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025"> <italic>KDM1A</italic> promotes cell proliferation via modulating E2F signaling.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Elevated <italic>KDM1A</italic> expression is associated with poor clinical outcome in oral cancer.</p> </list-item> </list> </p> </sec> </abstract>