Successful pregnancy in patients with exstrophy–epispadias complex: A University of Washington experience. Issue 4 (August 2015)

• Record Type: Journal Article
• Authors: Dy, Geolani W.; Willihnganz-Lawson, Katie H.; Shnorhavorian, Margarett; Delaney, Shani S.; Amies Oelschlager, Anne-Marie; Merguerian, Paul A.; Grady, Richard; Miller, Jane L.; Cheng, Edith Y.
• Is Part Of: Journal of pediatric urology. Volume 11:Issue 4(2015)
• Page Start: 213.e1
• Page End: 213.e6
• Publication Date: 2015-08
• Subjects: Pediatric urology -- Periodicals; Urologic Diseases -- Periodicals; Urogenital Diseases -- Periodicals; Urologic Surgical Procedures -- Periodicals; Child; Infant; Urologie pédiatrique -- Périodiques; Appareil urinaire -- Maladies -- Périodiques; Pédiatrie; Urologie; Pediatric urology; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); Electronic journals; Periodicals; Electronic journals; 618.926
• DOI: 10.1016/j.jpurol.2015.04.019
• Languages: English
• ISSNs: 1477-5131

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Introduction</title> <p id="abspara0010">With advances in genitourinary reconstructive surgery, women with exstrophy–epispadias complex (EEC) have improved health and quality of life, and may reach reproductive age and consider pregnancy. Despite literature suggesting impaired fertility and higher risk with pregnancy, childbirth is possible. Medical comorbidities, including müllerian anomalies, contribute to increased risk of obstetric and urologic complications during pregnancy.</p> </sec> <sec> <title id="sectitle0020">Objectives</title> <p id="abspara0015">We reviewed our experience with EEC patients who achieved pregnancy to investigate (1) urological characteristics of women who achieved pregnancy; (2) pregnancy management, complications, and delivery; and (3) neonatal outcomes. We developed recommendations for managing pregnancy in women with EEC.</p> </sec> <sec> <title id="sectitle0025">Study design/Results</title> <p id="abspara0020">This was a retrospective chart review of 36 female patients with EEC seen at our institution between 1996 and 2013. Female patients less than 18 years, and patients who did not have documented pregnancy were excluded. This resulted in a total of 12 patients with 22 pregnancies. All women with successful pregnancy had bladder exstrophy. The majority had undergone prior bladder augmentation (75%) and were on self-catheterization programs (92%). Thirty-six percent had symptomatic urinary tract infections (UTIs) during pregnancy. Five women had more than one pregnancy. There were four terminations of pregnancy. Of 18 desired pregnancies, there were four spontaneous abortions (SABs) (22%) and 16 live births (78%). The cesarean delivery (CD) rate was 100% (14/14), of which the majority were vertical (classical) uterine incisions with a paramedian skin incision. With the exception of one patient, there were no CD surgical complications. The mean gestational age at delivery was 36 weeks (Range 25 4/7 to 39 4/7 weeks) among eight pregnancies with known gestational age. There were no stillbirths, one neonatal death and no birth defects.</p> </sec> <sec> <title id="sectitle0030">Discussion</title> <p id="abspara0025">Women with EEC can have successful pregnancies, though at increased risk for preterm delivery and SABs. In our cohort, the rate of SAB is similar to that described in prior studies. Symptomatic UTIs likely due to self-catheterization were common. Cesarean delivery using a paramedian skin incision and classical uterine incision were not associated with major complications in this cohort. Limitations include reliance on retrospective data and small sample size. The strength of this study is the longitudinal detailed management of pregnancies in EEC women by a single team over time. A multidisciplinary approach to providing a continuum of care from pediatrics through adolescence to adulthood optimizes successful transitions, reproductive health, and successful pregnancies. Based on our experience, an algorithm providing guidance for pregnancy management was developed. <table-wrap id="dtbl" position="anchor"><label>Table</label><caption id="cap0010"><p id="tspara0010">Pregnancy resulting in live birth versus spontaneous abortion or termination.</p></caption><table border="1"><colgroup span="1"><col span="1" /><col span="1" /><col span="1" /><col span="1" /></colgroup><thead><tr valign="top"><th colspan="4" rowspan="1">Outcomes of 22 pregnancies in 12 EEC patients</th></tr><tr valign="top"><th rowspan="1" colspan="1">Outcome</th><th rowspan="1" colspan="1">Total pregnancies (<italic>n</italic> = 22)</th><th rowspan="1" colspan="1">Bladder exstrophy pregnancies (<italic>n</italic> = 20)</th><th rowspan="1" colspan="1">Cloacal exstrophy pregnancies (<italic>n</italic> = 2)</th></tr></thead><tbody><tr valign="top"><td rowspan="1" colspan="1">Total pregnancies</td><td align="char" char="(" rowspan="1" colspan="1">22 (100%)</td><td rowspan="1" colspan="1">20</td><td rowspan="1" colspan="1">2</td></tr><tr valign="top"><td rowspan="1" colspan="1">Spontaneous abortion <24 weeks</td><td align="char" char="(" rowspan="1" colspan="1">4 (18%)</td><td rowspan="1" colspan="1">3 (15%)</td><td rowspan="1" colspan="1">1 (50%)</td></tr><tr valign="top"><td rowspan="1" colspan="1">Terminations</td><td align="char" char="(" rowspan="1" colspan="1">4 (18%)</td><td rowspan="1" colspan="1">3 (15%)</td><td rowspan="1" colspan="1">1 (50%)</td></tr><tr valign="top"><td rowspan="1" colspan="1">Live births</td><td align="char" char="(" rowspan="1" colspan="1">14 (64%)</td><td rowspan="1" colspan="1">14 (70%)</td><td rowspan="1" colspan="1">0</td></tr></tbody></table></table-wrap></p> </sec> </abstract>