BAP1‐deficient and VE1‐negative atypical Spitz tumor. (12th June 2015)

• Record Type: Journal Article
• Authors: Requena, Celia; Sanz, Virginia; Nagore, Eduardo; García‐Casado, Zaida; Rubio, Luis; Guillén, Carlos; Kutzner, Heinz
• Is Part Of: Journal of cutaneous pathology. Volume 42:Number 8(2015:Sep.)
• Page Start: 564
• Page End: 567
• Publication Date: 2015-06-12
• Subjects: Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.12519
• Languages: English
• ISSNs: 0303-6987

Abstract

<abstract abstract-type="main" id="cup12519-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="cup12519-para-0001">Atypical Spitz tumor with loss of BAP1 or Wiesner nevus is a peculiar variant of intradermal spitzoid melanocytic neoplasm composed of epithelioid melanocytes with a sheet‐like growth pattern, abundant infiltrating lymphocytes and rare or absent mitotic activity. This subset of atypical spitzoid tumors is characterized by the BRAF^V600E mutation and loss of BAP1 expression. Recognition of these lesions is important because they can be a marker for a hereditary <italic>BAP1</italic>‐associated cancer syndrome. We present an unusual case of sporadic Wiesner nevus that had typical histopathologic features and a <italic>BAP1</italic> but not a <italic>BRAF</italic> mutation. The biological significance of Wiesner nevus is controversial, and little is known about prognosis, particularly in atypical cases like this one.</p> </abstract>