Change of Both Endocrine and Exocrine Insufficiencies After Acute Pancreatitis in Non-Diabetic Patients. Issue 27 (July 2015)

• Record Type: Journal Article
• Authors: Ho, Te-Wei; Wu, Jin-Ming; Kuo, Ting-Chun; Yang, Ching-Yao; Lai, Hong-Shiee; Hsieh, Su-Hua; Lai, Feipei; Tien, Yu-Wen; El-Halabi., Mustapha
• Is Part Of: Medicine. Volume 94:Issue 27(2015)
• Publication Date: 2015-07
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000001123
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Acute pancreatitis (AP) is the most common pancreatic disease and consists of an acute inflammation of the pancreas. AP can contribute to endocrine and exocrine insufficiencies in survivors as a result of the key role of the pancreas in both glucose metabolism and nutritional digestion. The aim of this population-based study was to determine the endocrine or exocrine insufficiencies in patients after initial AP with biliary or alcohol-associated causes.</p> <p>We conducted a nationwide cohort study using data from Taiwan's National Health Insurance Research Database collected between 2001 and 2010. A total of 12, 284 patients with AP were identified.</p> <p>Alcohol-associated AP (odds ratio, 1.894; 95% CI, 1.520–2.268; <italic>P</italic> < 0.001) and ≥2 admissions for AP (odds ratio, 1.937; 95% CI, 1.483–2.391; <italic>P</italic> < 0.001) were significantly associated with newly diagnosed diabetes mellitus after AP. Further, only alcohol-associated AP (odds ratio, 1.215; 95% CI, 1.133–1.297; <italic>P</italic> < 0.001) was significantly associated with pancreatic exocrine insufficiency after AP. Additionally, alcohol-associated AP (odds ratio, 1.804; 95% CI, 1.345–2.263; <italic>P</italic> < 0.001) and ≥2 readmissions for AP (odds ratio, 3.190; 95% CI, 2.317–4.063; <italic>P</italic> < 0.001) were significantly associated with both exocrine and endocrine insufficiencies after AP.</p> <p>Our data showed that alcohol-associated AP, rather than a biliary cause, contributed to a higher extent to exocrine or endocrine insufficiencies. Furthermore, recurrent AP also led to endocrine insufficiency.</p> </sec> </abstract>