Patch Testing To a Textile Dye Mix by the International Contact Dermatitis Research Group. Issue 4 (July 2015)

• Record Type: Journal Article
• Authors: Isaksson, Marléne; Ale, Iris; Andersen, Klaus E.; Diepgen, Thomas; Goh, Chee-Leok; Goossens R, An; Jerajani, Hemangi; Maibach, Howard I.; Sasseville, Denis; Bruze, Magnus
• Is Part Of: Dermatitis. Volume 26:Issue 4(2015:Jul./Aug.)
• Publication Date: 2015-07
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000125
• Languages: English
• ISSNs: 1710-3568

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series.</p> </sec> <sec> <title>Objective</title> <p>To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes.</p> </sec> <sec> <title>Methods</title> <p>Two thousand four hundred ninety-three consecutive dermatitis patients in 9 dermatology clinics were patch tested with a TDM 6.6%, consisting of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, all 1.0% each, and D Blue 106 and D Blue 124, each 0.3%. 90 reacted positively to the TDM. About 92.2% of the patients allergic to the TDM were also tested with the 8 separate dyes.</p> </sec> <sec> <title>Results</title> <p>Contact allergy to TDM was found in 3.6% (1.3–18.2) Simultaneous reactivity to <italic>p</italic>-phenylenediamine was found in 61.1% of the TDM-positive patients. Contact allergy to TDM and not to other p-amino–substituted <italic>sensitizers was diagnosed in 1.2%. The most frequent dye allergen in the TDM-positive patients was D Orange 3</italic>.</p> </sec> <sec> <title>Conclusions</title> <p>Over 30% of the TDM allergic patients had been missed if only the international baseline series was tested. Contact allergy to TDM could explain or contribute to dermatitis in over 20% of the patients. Textile dye mix should be considered for inclusion into the international baseline series.</p> </sec> </abstract>