Easier said than done: ABO compatibility and D matching in apheresis platelet transfusions. Issue 8 (11th March 2015)

• Record Type: Journal Article
• Authors: Dunbar, Nancy M.; Katus, Matthew C.; Freeman, Christine M.; Szczepiorkowski, Zbigniew M.
• Is Part Of: Transfusion. Volume 55:Issue 8(2015)
• Page Start: 1882
• Page End: 1888
• Publication Date: 2015-03-11
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.13077
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf13077-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Many hospital transfusion services prioritize ABO plasma compatibility in platelet (PLT) transfusion to minimize risk for acute hemolytic transfusion reactions. In spite of the low risk of D alloimmunization associated with apheresis PLT transfusion, attempts may also be made to provide D– PLTs to D– patients. This study was undertaken to assess how often ABO compatibility and/or D matching occurs at our institution and how the ABO and D mix of our PLT supply impacts PLT selection.</p> </sec> <sec id="trf13077-sec-0002" sec-type="section"> <title>STUDY DESIGN AND METHODS</title> <p>We retrospectively reviewed the ABO and D type of all PLTs transfused plus the age, sex, and ABO and D type of all PLT recipients between January 2010 and March 2014 (51 months).</p> </sec> <sec id="trf13077-sec-0003" sec-type="section"> <title>RESULTS</title> <p>We provided ABO‐identical PLTs for 5281 (54.6%), ABO plasma–compatible and cellular‐incompatible for 3136 (32.4%), ABO low‐titer plasma‐incompatible and cellular‐compatible for 1150 (11.9%), ABO plasma–incompatible and cellular‐compatible for 30 (0.3%), and ABO plasma–incompatible and cellular‐incompatible for 72 (0.7%). PLT supply did not match PLT demand based on patient ABO type, primarily due to a lower than expected supply of group O PLTs and higher than expected supply of group A and AB. D– patients were less likely to receive ABO‐identical PLT transfusions (p = 0.0008), but were more likely to receive D– PLT transfusions (p < 0.0001).</p> </sec> <sec id="trf13077-sec-0004" sec-type="section"> <title>CONCLUSION</title> <p>At our hospital, available inventory and PLT selection practices resulted in the majority of group O patients receiving cellular‐incompatible PLT transfusions. Efforts to provide D– PLTs to D– patients also resulted in fewer D– patients receiving ABO‐identical PLT transfusions.</p> </sec> </abstract>