New aryloxy-quinone derivatives as potential anti-Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis1. Issue 80 (2nd September 2015)

• Record Type: Journal Article
• Authors: Vázquez, Karina; Espinosa-Bustos, Christian; Soto-Delgado, Jorge; Tapia, Ricardo A.; Varela, Javier; Birriel, Estefanía; Segura, Rodrigo; Pizarro, Jaime; Cerecetto, Hugo; González, Mercedes; Paulino, Margot; Salas, Cristian O.
• Is Part Of: RSC advances. Volume 5:Issue 80(2015)
• Page Start: 65153
• Page End: 65166
• Publication Date: 2015-09-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra10122k
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2ds7qktp" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A set of new aryloxy-quinones were synthesized and evaluated <italic>in vitro</italic> against the epimastigote form of <italic>Trypanosoma cruzi</italic> and their unspecific cytotoxicity was tested on murine macrophages J-774 cells.</p> </abstract>