Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold1. Issue 32 (28th August 2015)

• Record Type: Journal Article
• Authors: Lanning, M. E.; Wilder, P. T.; Bailey, H.; Drennen, B.; Cavalier, M.; Chen, L.; Yap, J. L.; Raje, M.; Fletcher, S.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 32(2015)
• Page Start: 8642
• Page End: 8646
• Publication Date: 2015-08-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00478k
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2df4tss6" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Key residues on opposing faces of the Bak-BH3 α-helix were recapitulated by the 2, 6, 9-tri-substitution of a purine scaffold.</p> </abstract>