Japanese nationwide surveillance in 2011 of antibacterial susceptibility patterns of clinical isolates from complicated urinary tract infection cases. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Ishikawa, Kiyohito; Hamasuna, Ryoichi; Uehara, Shinya; Yasuda, Mitsuru; Yamamoto, Shingo; Hayami, Hiroshi; Takahashi, Satoshi; Matsumoto, Tetsuro; Minamitani, Shinichi; Kadota, Jun-ichi; Iwata, Satoshi; Kaku, Mitsuo; Watanabe, Akira; Sunakawa, Keisuke; Sato, Junko; Hanaki, Hideaki; Tsukamoto, Taiji; Kiyota, Hiroshi; Egawa, Shin; Deguchi, Takashi; Matsumoto, Minori; Tanaka, Kazushi; Arakawa, Soichi; Fujisawa, Masato; Kumon, Hiromi; Kobayashi, Kanao; Matsubara, Akio; Wakeda, Hironobu; Amemoto, Yoshinosuke; Onodera, Shoichi; Goto, Hirokazu; Komeda, Hisao; Yamashita, Masuo; Takenaka, Tadasu; Fujimoto, Yoshinori; Tsugawa, Masaya; Takahashi, Yoshito; Maeda, Hiroshi; Onishi, Hiroyuki; Ishitoya, Satoshi; Nishimura, Kazuo; Mitsumori, Kenji; Ito, Toru; Togo, Yoshikazu; Nakamura, Ichiro; Ito, Noriyuki; Kanamaru, Sojun; Hirose, Takaoki; Muranaka, Takashi; Yamada, Daisuke; Ishihara, Satoshi; Oka, Hiroya; Inatomi, Hisato; Matsui, Takashi; Kobuke, Makoto; Kunishima, Yasuharu; Kimura, Takahiro; Ichikawa, Takaharu; Kagara, Ichiro; Matsukawa, Masanori; Takahashi, Koichi; Mita, Koji; Kato, Masao; Okumura, Kazuhiro; Kawanishi, Hiroaki; Hashimura, Takayuki; Aoyama, Teruyoshi; Shigeta, Masanobu; Koda, Shuntaro; Taguchi, Keisuke; Matsuda, Yohei;
• Is Part Of: Journal of infection and chemotherapy. Volume 21:Issue 9(2015:Sep.)
• Page Start: 623
• Page End: 633
• Publication Date: 2015-09
• Subjects: Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2015.05.014
• Languages: English
• ISSNs: 1341-321X

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <p id="abspara0010">To investigate antimicrobial susceptibility patterns of various bacterial pathogens isolated from complicated urinary tract infection (UTI) cases, the Japanese Society of Chemotherapy, the Japanese Association of Infectious Disease, and the Japanese Society of Clinical Microbiology conducted the second nationwide surveillance from January to September 2011. With the cooperation of 42 medical institutions throughout Japan, 1036 strains belonging to 8 clinically relevant bacterial species were collected.</p> <p id="abspara0015">Among methicillin-resistant <italic>Staphylococcus aureus</italic> (MRSA) strain, the vancomycin (VCM) MIC for 5.5% (3/55) of the strains was 2 μg/mL. Ampicillin, VCM, and linezolid were relatively active against 209 <italic>Enterococcus faecalis</italic> strains. The proportion of fluoroquinolone (FQ)-resistant strains was >20%.</p> <p id="abspara0020">The MIC<sub>90</sub> of FQs against the 382 <italic>Escherichia coli</italic> strains was 2–64 mg/L and the proportion resistant to FQs was approximately 30%. However, susceptibility of <italic>E. coli</italic> to sitafloxacin was still high (MIC<sub>90</sub> = 2 mg/L). Fifty-eight (15.2%) of 382 <italic>E. coli</italic>, 6 (4.5%) of 132 <italic>Klebsiella pneumoniae</italic>, 1 (2.4%) of 41 <italic>Klebsiella oxytoca</italic> and 4 (6.8%) of 59 <italic>Proteus mirabilis</italic> strains were suspected of producing extended-spectrum beta-lactamase.</p> <p id="abspara0025">Of 93 <italic>Pseudomonas aeruginosa</italic> strains, the proportions resistant to imipenem, amikacin, and ciprofloxacin were 21.5%, 4.3%, and 20.4%, respectively. Four strains (4.3%) were found to be multidrug-resistant.</p> <p id="abspara0030">In complicated UTI cases, all of MRSA and <italic>E. faecalis</italic> were susceptible to all anti-MRSA agents. Sitafloxacin was active against other FQ-resistant <italic>E. coli</italic> strains. The isolation of extended-spectrum beta-lactamase-producing and multidrug-resistant strains increased.</p> </sec> </abstract>