Misoprostol versus prostaglandin E2 gel for labor induction in premature rupture of membranes after 34 weeks of pregnancy. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Zhang, Yan; Wang, Jun; Yu, Yan; Xie, Cui; Xiao, Meiqun; Ren, Lirong
• Is Part Of: International journal of gynaecology and obstetrics. Volume 130:Issue 3(2015:Sep.)
• Page Start: 214
• Page End: 218
• Publication Date: 2015-09
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1016/j.ijgo.2015.04.031
• Languages: English
• ISSNs: 0020-7292

Abstract

<abstract abstract-type="author" id="ab0005"> <title id="st0005">Abstract</title> <sec> <title id="st0010">Background</title> <p id="sp0005">Both misoprostol and prostaglandin E2 (PGE2) gel are used for labor induction in women with premature rupture of membranes (PROM).</p> </sec> <sec> <title id="st0015">Objectives</title> <p id="sp0010">To evaluate studies comparing the effects of misoprostol and PGE2 gel in labor induction.</p> </sec> <sec> <title id="st1015">Search strategy</title> <p id="sp0020">Databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant papers.</p> </sec> <sec> <title id="st1016">Selection criteria</title> <p id="sp0030">Randomized controlled trials comparing the use of misoprostol and PGE2 gel for labor induction in women with PROM were included.</p> </sec> <sec> <title id="st1017">Data collection and analysis</title> <p id="sp0040">For meta-analyses, the Mantel–Haenszel method was used for dichotomous data, and the inverse variance method was used for continuous data.</p> </sec> <sec> <title id="st1018">Main results</title> <p id="sp0050">Four randomized controlled studies (n = 615) were included. There were no significant differences between the two groups in the induction-to-delivery interval (mean difference – 4.44 hours; 95% confidence interval [CI] –9.35 to 0.48), rate of cesarean delivery (odds ratio [OR] 0.90; 95% CI 0.44–1.85), and rate of neonatal intensive care unit admission (OR 0.89; 95% CI 0.57–1.38). Women receiving misoprostol had a significantly higher rate of tachysystole than did those receiving PGE2 gel (OR 4.84; 95% CI 2.46–9.54).</p> </sec> <sec> <title id="st0020">Conclusions</title> <p id="sp0055">Misoprostol is as efficacious and safe as PGE2 gel for labor induction in women with PROM.</p> </sec> </abstract>