BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Acasigua, Gerson A.; Warner, Kristy A.; Nör, Felipe; Helman, Joseph; Pearson, Alexander T.; Fossati, Anna C.; Wang, Shaomeng; Nör, Jacques E.
• Is Part Of: Oral oncology. Volume 51:Issue 9(2015:Sep.)
• Page Start: 839
• Page End: 847
• Publication Date: 2015-09
• Subjects: Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2015.06.004
• Languages: English
• ISSNs: 1368-8375

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title id="st005">Highlights</title> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">BM-1197 is a new, potent, BH3 mimetics small molecule inhibitor of Bcl-2/Bcl-x_L</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">BM-1197 potently induces caspase-3 and apoptosis of adenoid cystic carcinoma cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">BM-1197 slows down tumor growth in PDX models of adenoid cystic carcinoma.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">BM-1197 prevents local recurrence of PDX tumors.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">These data unveil therapeutic potential of BH3-mimetics in adenoid cystic carcinoma.</p> </list-item> </list> </p> </sec> </abstract>